IRIBARREN PABLO
Artículos
Título:
Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain
Autor/es:
ARROYO, DANIELA S.; GAVIGLIO, EMILIA A.; PERALTA RAMOS, JAVIER M.; BUSSI, CLAUDIO; AVALOS, MARIA P.; CANCELA, LILIANA M.; IRIBARREN, PABLO
Revista:
Frontiers in Immunology
Editorial:
Frontiers
Referencias:
Año: 2018 vol. 9
Resumen:
cute brain injury leads to the recruitment and activation of immune cells includingresident microglia and infiltrating peripheral myeloid cells (MC), which contribute to theinflammatory response involved in neuronal damage. We previously reported that TLR2stimulation by peptidoglycan (PGN) from Staphylococcus aureus, in vitro and in vivo,induced microglial cell activation followed by autophagy induction. In this report, weevaluated if phosphatidyl-inositol-3 kinase (PI3K) pharmacological inhibitors LY294200and 3-methyladenine (3-MA) can modulate the innate immune response to PGNin the central nervous system. We found that injection of PGN into the mouse brainparenchyma (caudate putamen) triggered an inflammatory reaction, which involvedactivation of microglial cells, recruitment of infiltrating MC to injection site, productionof pro-inflammatory mediators, and neuronal injury. In addition, we observed the accumulationof