Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration

PERALTA RAMOS, JAVIER MARÍA; IRIBARREN, PABLO; BOUSSET, LUC; MELKI, RONALD; BAEKELANDT, VEERLE; VAN DER PERREN, ANKE

Frontiers in Immunology

Frontiers Media S.A.

Año: 2019 vol. 10

nnate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson´s disease (PD) and may contribute to the pathophysiology of the disease. The discovery of misfolded alpha-synuclein (αSYN) protein aggregates, which amplify in a ?prion-like? fashion, has led us to consider that pathogenic αSYN might be hijacking the activation and mobilization mechanism of the peripheral immune system to reach and disseminate within the CNS. Furthermore, our lab and other groups have recently shown that αSYN can adopt distinct fibril conformations or ?strains? with varying levels of pathogenic impact. Therefore, the aim of this study was to assess the impact of peripheral inflammation on αSYN spreading in order to better understand the participation of the immune system in the progression of PD. The results presented here show that intraperitoneal LPS injection prior to systemic intravenous recombinant administra