Expression of bone morphogenetic protein receptors in bovine oviductal epithelial cells: Evidence of autocrine BMP signaling

VALDECANTOS, PABLO ALBERTO; BRAVO MIANA, ROCÍO DEL CARMEN; GARCÍA, ELINA VANESA; GARCÍA, DANIELA CELESTE; ROLDÁN-OLARTE, MARIELA; MICELI, DORA CRISTINA

ANIMAL REPRODUCTION SCIENCE

ELSEVIER SCIENCE BV

Año: 2017 vol. 185 p. 89 - 89

0378-4320

embers of the transforming growth factor beta (TGF-β) family, including bone morphogenetic proteins (BMPs), are expressed in the epithelial cells of the mammalian oviduct. These signaling molecules play important roles in development and tissue homeostasis; however, little is known about their function in the mammalian oviduct. In the present study, RT-qPCR was used to analyze the mRNA abundance of BMP type I (BMPR1A, BMPR1B, ACVR1) and type II receptors (BMPR2, ACVR2A, ACVR2B) in the bovine oviduct epithelial cells (BOEC) isolated from ampulla and isthmus at both the follicular (FP) and the luteal (LP) phase of the estrous cycle. Results indicate that mRNAs for all the BMP receptors studied are expressed in the BOEC. Significant mRNA abundance differences were observed for both BMPR1B and ACVR2B when comparing both the ampulla and isthmus regions with the greater abundance at the isthmus. When both FP and LP samples were compared, ACVR2B mRNA showed greater abundance during the