A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained 3 release of antigen and has intrinsic pro-inflammatory and adjuvant activities which 4 are dependent on MyD88 adaptor protein

FERNANDA SÁNCHEZ-VALLECILLO; MARÍA MINGUITO DE LA ESCALERA; MARÍA VIRGINIA AGUIRRE; GABRIELA ULLIO; SANTIAGO PALMA; LETICIA GONZALEZ-CINTADO; ANA CHIODETTI; GERMAN SOLDANO; G MORON; DANIEL ALLEMANDI; CARLOS ARDAVÍN; MARÍA C PISTORESI- PALENCIA.; BELKYS A. MALETTO

JOURNAL OF CONTROLLED RELEASE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 214 p. 12 - 12

0168-3659

!--[if gte mso 9]> Immunobiology. 10.1016/j.imbio.2012.02.004 N.A. Kahle 15.00 Modern subunitvaccines require the development of new adjuvant strategies. Recently, weshowed that CpG-ODN formulated with a liquid crystal nanostructure formed byself assembly of 6-O-ascorbyl palmitate (Coa-ASC16) is an attractive system forpromoting an antigen-specific immune response to weak antigens. Here, we showedthat after subcutaneous injection of mice with near-infrared fluorescentdye-labeled OVA antigen formulated with Coa-ASC16, the dye-OVA was retained atthe injection site for a longer period than when soluble dye-OVA wasadministered. Coa-ASC16 alone elicited a local inflammation, but how thismaterial triggers this response has not been describe