Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment

FLORENCIA HARMAN; ROMINA P. RANOCCHIA; CAROLINA GORLINO; FERNANDA SÁNCHEZ-VALLECILLO; SOFÍA CASTELL; MARÍA INÉS CRESPO; BELKYS A. MALETTO; G MORON; MARÍA C. PISTORESI-PALENCIA

Oncotarget

Impact Journals, LLC

Año: 2015 vol. 6 p. 13448 - 13448

!--[if gte mso 9]> As we age, thehomeostatic function of many systems in the body, such as the immune functiondeclines, which in turn contributes to augment susceptibility to disease. Herewe describe that challenging aged mice with synthetic oligodeoxynucleotides containingunmethylated cytosine guanine motifs (CpG-ODN) emulsified in incomplete Freund?sadjuvant (IFA), (CpG-ODN+IFA) an inflammatory stimulus, led to the expansion ofCD11b+Gr1+