Class-B CpG-ODN formulated with a nanostructure induces type I interferons-dependent and CD4+ T cell-independent CD8+ T-cell response against unconjugated protein antigen

ANA CHIODETTI; FERNANDA SÁNCHEZ-VALLECILLO; JOSEPH DOLINA; MARÍA INÉS CRESPO; CONSTANZA MARIN; STEPHEN SCHOENBERGER; DANIEL ALLEMANDI; SANTIAGO PALMA; MARÍA C PISTORESI- PALENCIA; GABRIEL MORON; BELKYS A. MALETTO

Frontiers in Immunology

Frontiers

Lugar: Lausanne; Año: 2018

p class="MsoNormal" style="">There is a need for new vaccine adjuvant strategiesthat offer both vigorous antibody and T-cell mediated protection to combat difficult intracellularpathogens and cancer. To this aim, we formulated class-B synthetic oligodeoxynucleotidecontaining unmethylated cytosine-guanine motifs