Orally Administered OVA/CpG-ODN Induces Specific Mucosal and Systemic Immune Response in Young and Aged Mice

DIEGO ALIGNANI; BELKYS MALETTO; MIRIAM LISCOVSKY; ANDREA RÓPOLO; GABRIEL MORÓN; MARÍA C. PISTORESI-PALENCIA

FEDERATION AMER SOC EXP BIOL

Año: 2005 vol. 77 p. 898 - 898

b> We have previously demonstrated that subcutaneously administered ovalbumin (OVA) plus synthetic oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG-ODN) as adjuvant stimulate cellular and humoral immunity and promote T helper cell type 1 differentiation in aged mice. The present study assessed the ability of CpG-ODN to induce an OVA-specific immune response after oral immunization in young (3-monthold) and aged (18-month-old) BALB/c mice. Oral OVA/CpG-ODN immunization induces a similar OVA-specific T cell-proliferative response (in mucosal and systemic tissues), immunoglobulin G (IgG) in plasma