Presence of neutrophil bearing antigen in lymphoid organs of immune mice

BELKYS A. MALETTO; ANDREA S. RÓPOLO; DIEGO O. ALIGNANI; MIRIAM V. LISCOVSKY; ROMINA P. RANOCCHIA; GABRIEL MORÓN; MARÍA C. PISTORESI-PALENCIA

AMER SOC HEMATOLOGY

Año: 2006 vol. 108 p. 3094 - 3094

p class="MsoNormal" style="margin: 0cm 0cm 0pt;">Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-labeled OVA was injected into the footpad of OVA/CFA immunized mice, the main OVAFITC  cells recruited in draining popliteal lymph nodes (LNs) were neutrophils, with most of them arriving at the LN by means of lymphatic vessels. The development of this OVA-FITC_