β-cyclodextrin complexation as an approach to enhance the biopharmaceutical properties of Norfloxacin B Hydrate

BUENO MARIA SOLEDAD; CHIERENTIN LUCAS; BONGIOANNI AGUSTINA; NUNES SALGADO HERIDA; LONGHI MARCELA; GARNERO CLAUDIA

CARBOHYDRATE RESEARCH

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2019

0008-6215

inary systems of Norfloxacin B Hydrate with β-CD were explored by reliable biopharmaceutical studies as potential candidates for the preparation of drug delivery systems. Initially, studies of antimicrobial activity and solubility of the different polymorphic forms of Norfloxacin provided evidence to select Norfloxacin B Hydrate as the optimal solid form of Norfloxacin. Solid binary systems were preparing by kneading, freeze-drying, and physical mixture methods. The influence on the solubility, dissolution rate and chemical stability of Norfloxacin B Hydrate was investigated. These studies showed an increment of solubility and dissolution rate in physiological simulated fluids. However, the solid systems were moderated hygroscopically under accelerated storage conditions, which produces a destabilizing effect that accelerated the chemical reactivity of the drug in such conditions. Therefore, special cares must be considered in the manufacturing process and the packaging selection