BUENO MARIA SOLEDAD
Artículos
Título:
Exploring solid forms of oxytetracycline hydrochloride
Autor/es:
BUENO, MARIA S.; MIÑAMBRES, GUADALUPE G.; BONGIOANNI, AGUSTINA; CHATTAH, ANA K.; AIASSA, VIRGINIA; LONGHI, MARCELA R.; GARNERO, CLAUDIA
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2020 vol. 585
ISSN:
0378-5173
Resumen:
xytetracycline hydrochloride, an antibiotic of the tetracycline family, is a polymorphic drug that evidences erratic absorption in oral administration. Additionally, poor solid state characterization of the polymorphs and diversity in the existing nomenclature impede the correct identification of the raw materials. In this work, oxytetracycline hydrochloride solid forms were prepared from isopropyl alcohol, ethanol and methanol through different crystallization techniques, and then their physicochemical and microbiological properties were evaluated. A combination of advanced techniques such as solid state nuclear magnetic resonance, powder X-ray diffraction, infrared spectroscopy, thermal analysis, scanning electron microscopy and energy-dispersive X-ray spectroscopy were used in the characterization of solid samples giving clear evidence of the existence of three stable and one metastable solid forms of the oxytetracycline hydrochloride. Solubility was determined in aqueous solution,