Synthesis and characterization of novel β-cyclodextrin-grafted chitosan hydrogels

SERGIO R. RIBONE ; JUAN P. CERUTTI ; WOUT DE LEGER; DAN CÓRDOBA ANTONELLA DEL V.; MARCELA R. LONGHI ; MARIO A. QUEVEDO ; MARIO SMET ; WIM DEHAEN ; ZOPPI ARIANA

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICIFA 2020+1); 2021

The design and development of hydrogels obtained by combination of chitosan and cyclodextrin constitutes a highly relevant scientific topic towards the obtention of controlled release polymeric matrices. The main purpose of this study was the synthesis and characterization of novel β-cyclodextrin-grafted chitosan (CD-f-CS) hydrogels, intended to be employed as sustained drug delivery devices. The CD-f-CS hydrogels were synthesized by reductive amination using monoaldehyde-β-CD and different ketones, whose molar ratio was varied to diversify the resulting hydrogels. The successful grafting of β-CD onto chitosan was confirmed by FTIR and NMR. The morphology of the hydrogels was characterized by SEM, showing a porous structure; and their viscoelastic properties were studied by rheological measurements. The storage modulus (G′) was always higher than the loss modulus (G″) and there were no crossover points, indicating that the hydrogels have the characteristic gel structure. By increasing the length and/or the amount of the ketone used for their synthesis, weaker and more stable hydrogels with larger pore size are obtained. The observed rheological behavior suggests that synthesized CD-f-CS are expected to be efficient drug delivery carriers.