Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts

RICARDO ROJAS; YAMILA GARRO LINCK; SILVIA L. CUFFINI; GUSTAVO A. MONTI; CARLA E. GIACOMELLI

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 109 p. 119 - 119

ayered double hydroxides (LDH) and Zn layered hydroxide salts (LHS) present different physicochemical and interfacial properties derived from their dissimilar structure and composition, which affect the release behavior of the intercalated drug. In this work, these aspects are studied using LDH and LHS intercalated with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) to understand the behavior of intercalation compounds as drug carriers. The structure of the solids and the interaction mode between the drugs and the layers were determined by chemical analysis, PXRD, FTIR and NMR. Further, the interfacial properties (potential zeta and hydrophillic/hydrophobic character) of the solids, as well as their drug release profiles were also comparatively studied. The drugs were attached by electrostatic interactions to LDH layers while coordinate bond was produced in the case of LHS. The different interaction modes, together with the higher drug density between LHS layers produced more cry