Effect of the protein corona on the colloidal stability and reactivity of LDH-based nanocarriers

CECILIA VASTI; DARIANA ARISTIZABAL BEDOYA; RICARDO ROJAS; CARLA E. GIACOMELLI

JOURNAL OF MATERIALS CHEMISTRY

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2016 vol. 4 p. 2008 - 2008

0959-9428

he physicochemical properties of drug nanocarriers such as layered double hydroxide nanoparticles (LDH-NPs) determine their circulation times in biological media and their interaction with the targeted cells. Nevertheless, the components of the biological fluid, and particularly the formation of a protein corona, change the properties of as-prepared nanocarriers. Here, we discuss the effect of the protein corona formation on the colloidal stability and reactivity of LDH-NPs intercalated with chloride (LDH?Cl), carbonate (LDH?CO3) or dodecylsulfate (LDH?DS). These solids present model physicochemical properties (hydrophillic character, surface charge, and exchange capacity) that can be obtained depending on the interaction of drugs with LDH layers. The colloidal stability of LDH-NPs was determined in simulated biological fluids at high ionic strength and/or the presence of albumin (the main protein of human blood plasma), whereas the reactivity was evaluated by dissolution kinetics in