Restorative effect of Insulin-like Growth Factor-I Gene Therapy in the Hypothalamus of senile rats with Dopaminergic dysfunction

HEREÑU CB; CRISTINA C; RIMOLDI O; BECÚ-VILLALOBOS D; CAMBIAGGI V; PORTIANSKY E; GOYA R.

Nature Publishing group

Lugar: Londres; Año: 2007 vol. 14 p. 237 - 237

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%">SUMMARY-Hereñú - Gene Therapy 2006 Insulin-like growth factor I (IGF-I) is emerging as a powerful neuroprotective molecule which is strongly induced in the central nervous system after different insults. We constructed a recombinant adenoviral vector (RAd-IGFI) harboring the gene for rat IGF-I  and used it to implement IGF-I gene therapy in the hypothalamus of senile female rats, which display hypothalamic dopaminergic (DA) neurodegeneration and as a consequence, chronic hyperprolactinemia. Restorative IGF-I gene therapy was implemented in young (5 mo.) and senile (28 mo.) female rats, which received a single intrahypothalamic injection of 3 X109