Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.

MITSCHELEN M; YAN H; FARLEY JA; WARRINGTON JP; HAN S; HEREÑU C; CSISZAR A; UNGVARI Z; BAILEY-DOWNS LC; BASS CE; SONNTAG W.E.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2011 vol. 30 p. 50 - 50

p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 10pt" class="MsoNormal">ABSTRACT Numerous studies support the hypothesis that insulin-like growth factor I (IGF-1) deficiency in adults may cause depression, but direct evidence is limited.  Many other psychological and pro-cognitive effects have been attributed to IGF-1, but appropriate animal models of adult-onset IGF-1 deficiency are lacking.  The need for such models is highlighted by the characteristic decline of IGF-1 in