Magnetic field-assisted gene delivery: achievements and therapeutic potential

SCHWERDT J; GOYA GERARDO; CALATAYUD PILAR; HEREÑÚ C.B; REGGIANI PC,; GOYA R.G,

BENTHAM SCIENCE PUBL LTD

Lugar: Karachi; Año: 2012 p. 25 - 25

font face="TimesNewRomanPSMT"> The discovery in the early 2000’ that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another novel technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strateg