Rejuvenation by cell reprogramming: A new horizon in gerontology

GOYA, RODOLFO G.; LEHMANN, MARIANNE; CHIAVELLINI, PRISCILA; CANATELLI-MALLAT, MARTINA; HEREÑÚ, CLAUDIA B.; BROWN, OSCAR A.

Stem Cell Research and Therapy

BioMed Central Ltd.

Lugar: Amsterdan; Año: 2018 vol. 9

he discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath´s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rode