Novel adenoviral IGF-I administration modulates the association between depressive symptoms and aging: Does gender matter?

HERRERA, MACARENA LORENA; BASMADJIAN, OSVALDO MARTÍN; LOCKHART, EUGENIA FALOMIR; DOLCETTI, FRANCO JUAN-CRUZ; HEREÑÚ, CLAUDIA B*EQUALLY CONTRIBUTION); BELLINI, MARIA J.*EQUALLY CONTRIBUTION

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Año: 2019

0166-4328

bstractDepression is an illness of multifactorial origin and it seems to involve the dysregulation of many physiological processes. It also has been associated with age and a decreased in the expression of some neurotrophins.However, there are not unique animal models to assay depressive-like behavior, with male and females responding differently. In this study, we report the effects of gender on aged associated depressive signs as frailty,muscular strength and motor activity, as well as the role of intramuscular IGF-1 gene therapy in these processes. We found that male mice had higher general discomfort than females. Moreover, we observed that IGF-1treatment did not modify this index in females. Regarding male mice, adenoviral IGF-1 injection reduced frailty scores compared to its adenoviral control.According to data, IGF-1 gene therapy had a positive effect on depressive associated hypo-locomotion activity as indicate by delta of total distance and the increment observed in time of