Sex frailty differences in ageing mice: Neuropathologies and therapeutic projections

HERRERA, MACARENA LORENA; BASMADJIAN, OSVALDO MARTIN; FALOMIR LOCKHART, EUGENIA; DOLCETTI, FRANCO JUAN CRUZ; HEREÑÚ CLAUDIA* EQUALLY CONTRIBUTION); BELLINI, MARIA J.* EQUALLY CONTRIBUTION

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Año: 2020

0953-816X

bstractIt is well‐established that females live longer than males. Paradoxically, women tend to have poorer health, a condition often named sex frailty. The aim of this study was to evaluate possible frailty predictors in older mice in a sex‐specific manner, in order to employ these predictors to follow‐up therapy efficiency. To further evaluate therapy effects, we also investigated the use of neurotrophic insulin‐like growth factor 1 (IGF‐1) gene therapy and its correlation with the expression of this frailty and emotional behaviour. In order to evaluate frailty, we employed two different approaches. We performed a frailty assessment through a 31‐Item Clinical Frailty Index and through a Performance‐Based 8‐Item Frailty Index. Our results show that both indexes are in concordance to evaluate sex differences, but they do not correlate when evaluating IGF‐1 therapy effects. Moreover, in order to reduce test‐to‐test varia