Relation between biophysical properties of nanostructures and their toxicity on zebrafish

MARTINEZ, CAROLINA S.; IGARTUA DANIELA; CALIENNI, NATALIA; FEAS, DANIELA; SIRI, MACARENA; MONTANARI, JORGE; CHIARAMONI NADIA S.; ALONSO SILVIA DEL V.; PRIETO JIMENA

Biophysical Reviews

Springer Verlag

Año: 2017

1867-2450

n recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro- and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effect. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish.