Media interaction and stability of a gamma irradiated albumin nanoparticle

SIRI MACARENA

JOURNAL OF BIOTECHNOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2020

0168-1656

p class="MsoNormal" style="text-align: justify;">Protein nanoparticledesigning at the nanoscale is challenging because of protein vulnerability tochemical and physical degradation during processing and biodistribution. Wepresent a crosslinked gamma irradiated albumin-based nanoparticle as apotential drug delivery system. The focus was set on the study of thenanoparticle under adverse experimental conditions: different pH values, SDS,tween 80 and urea. The albumin-based nanoparticle was also tested against timestability and ionic strength solutions.Regardingits stability against pH, the nanoparticle showed similarity to the behaviourof albumin, whilst the stability of the nanoparticle improved in urea and Tween80. The nanoparticle was stable for 15 days, and presented