Potential of goat probiotic to bind mutagens

ANA LIDIA APAS; SILVIA NELINA GONZALEZ; MARIO EDUARDO ARENA

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2014 vol. 28 p. 8 - 8

DL 48, Enterococcus faecium DDE 39, and Bifidobacterium bifidum DDBA) was evaluated. The oral administration of these probiotics reduced fecal mutagens and intestinal cancer markers in goats. Secondly,the effects of probiotics against the mutagenesis induced by sodium azide (SA), and Benzopyrene(B[a]P) by performing the modified Ames test using Salmonella typhimurium TA 100 was investigated. The capacity to bind benzopyrene and the stability of the bacterialemutagen complex was analyzed by HPLC. The dismutagenic potential against both mutagens was proportional to probiotic concentration.Results showed that probiotic antimutagenic capacity against SA was ranging from 13 to 78%. The mixture of four goat probiotics (MGP) displayed higher antimutagenic activity against SA than any individual strains at the same cell concentration. This study shows that the highest diminution of mutagenicity in presence of B[a]P (74%) was observed in presence of MGP. The antimutagenic activity of nearly