Sustained dual release of ciprofloxacin and lidocaine from ionic exchange responding film based on alginate and hyaluronate for wound healing

ANA LIDIA APAS

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2021

0928-0987

his study presents a new antibiotic-anesthetic film (AA-film) based on natural polyelectrolytes ionically complexedwith lidocaine and ciprofloxacin to manage pain associated with infected wounds. The rational selectionof the components resulted in the AA-films being transparent, compatible with wound skin pH and highly water vapor permeable. The drug release properties evaluated in saline solution and water revealed an ionic exchangemechanism for the release of both drugs and showed that ciprofloxacin acts as a cross-linker, as was confirmed by rheological evaluation. The in vitro antimicrobial efficacy against S. aureus and P. aeruginosa was demonstrated.Furthermore, AA-films exhibit a high fluid absorption capacity and act as a physical barrier for microorganisms.This work highlights the great potential of this smart system as an attractive dressing for skin wounds, surpassingcurrently available treatments