Development of a new antimicrobial agent with a promising use in wound healing management

USSEGLIO, NADINA ; PAEZ, PAULINA; ONNAINTY, RENÉE; CARRER, DOLORES; GRANERO, GLADYS

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencia 2019; 2019

SAFE, SAIC, SAB, SAP

In the vast world of medicine there are several fields of study of interest; one of them is wound healing. Wounding leads to exposure of subcutaneous tissue that provides a nutritious environment conductive to microbial colonization and proliferation. The presence of bacteria at the wound site down regulates the host immune response, ultimately delaying the natural wound healing process, making the total healing time unpredictable. The usefulness of silver as an antimicrobial agent has been known for a long time. It´s especially important in the topical antibacterial treatment of burn wounds. The most widely use reagents have been silver nitrate and silver sulfonamides. However, they have showed a limited clinical usefulness.The aim of this work is to develop a new water-soluble silver complex formed with triethanolamine (TEA) and silver nitrate (AgNO3) for use in wound healing treatment. The antimicrobial activity of the developed silver complex was tested against S. aureus by determining its Minimum Inhibitory Concentration (MIC). The potential cytotoxicity effect was assessed in vitro against L929 fibroblasts.Antimicrobial results showed that the silver complex displays effective antimicrobial activity comparable to MIC values of AgNO3.This study sets a platform for further work for the use of the novel developed silver complex from the wound care application perspective.