Resumen:
he aim of this work was to increase the aqueous solubility and the dissolution rate of NOR by the preparation of binary and ternary complexes with hydroxypropyl-B-cyclodextrin (HPBCD), using glutamic acid (GA), proline (PRO) or lysine (LIS) as the third component. Complexation in solution was evaluated by phase solubility studies, obtaining the greatest increase in NOR solubility when combined with GA and HPBCD, with respect to the solubility obtained for the corresponding binary complexes. The solid state studies were performed by thermal analysis, which suggested that different kinds of interaction occur among NOR, HPBCD and each AA and when the systems were prepared by kneading or lyophilization technique. Dissolution studies, performed on simulated gastric fluid (2 h) and subsequent simulated intestinal fluid (4 h following), showed the highest dissolution rate of NOR from the ternary systems with HPBCD and GA, with respect to the complexes formed by HPßCD and the other AA, indica