Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high fat diet-induced obesity

KELLEY EE; BAUST J; BONACCI G; GOLIN-BISELLO F; DEVLIN JE; ST CROIX CM; WATKINS SC; GOR S; CANTU-MEDELLIN N; WEIDERT ER; FRISBEE JC; GLADWIN MT; CHAMPION HC; FREEMAN BA; KHOO NKH

OXFORD UNIV PRESS

Lugar: Oxford; Año: 2014 vol. 101 p. 352 - 352

IMS: Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator secretion from visceral AT and the initiation of pro-inflammatory events that induce oxidative stress and tissue dysfunction. Current understanding supports that suppressing pro-inflammatory and oxidative events promotes improved metabolic and cardiovascular function. In this regard, electrophilic nitro-fatty acids display pleiotropic anti-inflammatory signalling actions. METHODS AND RESULTS: It was hypothesized that high-fat diet (HFD)-induced inflammatory and metabolic responses, manifested by loss of glucose tolerance and vascular dysfunction, would be attenuated by systemic administration of nitrooctadecenoic acid (OA-NO2). Male C57BL/6j mice subjected to a HFD for 20 weeks displayed increased adiposity, fasting glucose, and insulin l