Biochemical and structural information transduction at the mesoscopic level in biointerfaces containing sphingolipids.

RAFAEL GUSTAVO OLIVEIRA; FANANI, M. L.; MAGGIO, B.

NEUROCHEMICAL RESEARCH

Springer New York

Año: 2002 vol. 27 p. 547 - 547

0364-3190

n this work we describe two aspects of molecular and supramolecular information transduction.The first is the biochemical and structural information content and transduction associatedwith sphingomyelinase activity. The results disclose a lipid-mediated cross-communication between the sphingomyelinase and phospholipase A2 pathways. In addition, the two-dimensionaldegradation of sphingomyelin by sphingomyelinase affects the surface topography and the lattermodulates the enzyme activity. The second is the information contained in the compositionallydriven lateral organization of whole glial and neuronal membrane interfaces. The myelin monolayer exhibits microheterogeneous topographical structuring and nonhomogeneouslateral thickness of phase separated regions, depending dynamically on the lateral surface pressure. On the other hand, the differential response of functional living cells depends on information contained in the molecular organization of t