Chlamydia muridarum INDUCE THE EXPRESSION OF CO-INHIBITORY MOLECULES ON IMMUNE CELLS

OLIVERA, CAROLINA; GODOY GLORIA JANET; SALAZAR FLORENCIA; PAIRA DANIELA ANDREA; MOTRICH, RUBÉN DARÍO; RIVERO, VIRGINIA ELENA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias 2017; 2017

SAI SAIC SAFE SAIB SAH SAP SAP SAB SAFIS SAA

Chlamydia trachomatis is the most commonly reported agent of sexually transmitted bacterial infections worldwide. This pathogen frequently leads to long-term persistent subclinical infections, both in male and female. This is in part due to certain mechanisms, not yet fully elucidated, that suppress the immune response to the pathogen.Recently, the role of co-inhibitory pathways in some chronic infections has been studied, and reports suggested that the overexpression of co-inhibitory molecules would be related to pathogen persistence.PD-L1 the primary regulatory counter-receptor for PD1 in the peripheral tissue is broadly inducible in various tissues and cell types . The interaction between PD1 and PD-L1 plays a critical rol in determining the fate of T cell activation and tolerance during T-cell priming.