Most of anti-glycolipid IgG-antibodies associated to neurological disorders occur without their IgM counterpart

LARDONE, RICARDO DANTE; IRAZOQUI, FERNANDO JOSÉ; NORES, GUSTAVO ALEJANDRO

JOURNAL OF BIOMEDICAL SCIENCE

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2019 vol. 26

1021-7770

ackground: Different neurological disorders frequently display antibodies against several self-glycans. Increasing evidence supports their pathogenic role; however, far less is known about their origin. Meanwhile, antibodies recognizing non-self glycans appear in normal human serum during immune response to bacteria. Methods: Using high performance thin layer chromatography-immunostaining, we comparatively evaluated humoral immune response (IgG and IgM immunoreactivity) against glycolipids carrying self-glycans (GM3/GM2/GM1/GD1a/GD1b/GD3/GT1b/GQ1b) and non-self glycans (Forssman/GA1/"A" blood group/Nt7) in sera from 383 patients with neurological disorders along with 87 healthy controls. Results: In contrast to no healthy controls having anti-self glycan IgG antibodies, one-fifth of patients´ sera had anti-self glycan IgG antibodies: remarkably, 60% of these occurred without IgM antibodies of the same specificity. Contrary to this unusual fact (anti-self glycan IgG occurrence without