Oxalate induces Breast Cancer

ANDRES CASTELLARO; HUGO CEJAS ; ALFREDO TONDA; HECTOR FERREYRA; BEATRIZ CAPUTTO; OSCAR PUCCI; GERMAN A GIL

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2015

bstract Introduction: One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications. Clustered microcalcifications are one of the mammographic hallmarks routinely used to detect breast cancer in its initial stages, which is of key importance due to the possibility that early detection gives for the application of more conservative therapies for a better patient outcome. The mechanism by which mammary microcalcifications are formed is still largely unknown but breast cancers presenting microcalcifications are more often associated with a poorer prognosis. Methods: We combined Capillary Electrochromatography, histology, and gene expression to analyze patient-matched normal breast tissue vs. breast tumor. Differential gene expression analyses were performed by qRT-PCR. Potential carcinogenicity of oxalate was tested by its inoculation into mice. Results: To study the biological significance of oxalates within the breast tumor microenv