Magnetic layered double hydroxides with carbamazepine for breast cancer treatment

PERALTA, M. FLORENCIA; MENDIETA, SILVIA N.; SCOLARI, I. ROMINA; GERBALDO, M. VERÓNICA; OLIVA, MARCOS I.; GIL, GERMÁN A.; GRANERO, GLADYS E.; CRIVELLO, MÓNICA E.

Heliyon

Elsevier

Lugar: Amsterdam; Año: 2023 vol. 9

2405-8440

urrent cancer chemotherapy is associated with many side effects and, in some cases, drug resistance, which makes the search for new active molecules and drug delivery strategies imperative. Carbamazepine is an antiepileptic compound that has shown efficacy against breast cancer cell lines. In this study, it was incorporated into layered double hydroxide nanoclays, the percentage of drug loading was increased compared to previous research, and the clays were impregnated with magnetic Fe3O4 nanoparticles. The goal of the magnetic Fe3O4-impregnation was to direct the nanocomposites to the therapeutic target with an external magnetic field. The nanoclay-carbamazepine composites had a carbamazepine loading of 51 %, and the nanoclay-carbamazepine-nanoparticles had a drug loading of 13 % due to the addition of more ingredients. The structure of the composites was analyzed by X-ray diffraction and Scherrer equation, showing a layered double hydroxide organization with crystal sizes of 9–15 nm