Magnetic nano composites for gallic acid delivery

PERALTA, M.FLORENCIA; MENDIETA, SILVIA N.; SCOLARI, I. ROMINA; OLIVA, MARCOS I.; GIL, GERMÁN A.; GRANERO, GLADYS E.; CRIVELLO, MÓNICA E.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

EDITIONS SANTE

Año: 2024 vol. 92

1773-2247

new magnetic layered double hydroxide (MLDH) composed of Fe, Mg, and Al was designed to improve gallic acid delivery to breast tumors. The metals formed the octahedrons within the layers, while the gallate ions were dissolved in the aqueous interlayer space. The drug loading was 30 %, determined with UV/Vis spectrophotometry. The material exhibited superparamagnetic behavior with a saturated magnetization of 5.5 emu/gr. This magnetic property enables the compound to be directed towards the therapeutic target using an external magnetic field, while the superparamagnetic attribute prevents the material from remaining magnetized in the body after the external magnetic field is removed. The diameter of the composites, measured from TEM images, was 110 nm: small enough for systemic circulation. For comparison, a conventional layered double hydroxide composed of Mg and Al was loaded with gallic acid and impregnated with Fe3O4 magnetic nanoparticles (LDH-NP). The drug loading was slightly l