Electrochemical quantification of 2,6-diisopropylphenol (propofol)

JAN LANGMAIER; FERNANDO GARAY; FRANCINE KIVLEHAN; EDWARD CHAUM; ERNO LINDNER

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2011 vol. 704 p. 63 - 63

,6-Diisopropylphenol (propofol) is a potent anesthetic drug with fast onset of the anesthetic effect and short recovery time for the patients. Outside of the United States, propofol is widely used in performing target controlled infusion anesthesia. With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution. When the electrochemical oxidation of propofol takes place on a glassy carbon working electrode, an electrochemically active film grows on the electrode surface. The reduction current of the film is proportional to the propofol concentration and the accumulation time. Based on these findings a stripping analytical method was developed for the detection of propofol in acidic solutions between 0 and 30 µM, with a detection limit of (5.5 ± 0.4)