Toward Feedback-Controlled Anesthesia: Voltammetric Measurement of Propofol (2,6-Diisopropylphenol) in Serum-Like Electrolyte Solutions

FRANCINE KIVLEHAN; FERNANDO GARAY; JIDONG GUO; EDWARD CHAUM; ERNÖ LINDNER

AMER CHEMICAL SOC

Lugar: Washington; Año: 2012 vol. 84 p. 7670 - 7670

ropofol is a widely used, potent intravenous anesthetic for ambulatory anesthesia and long-term sedation. The target steady state concentration of propofol in blood is 0.25−10 μg/mL (1−60 μM). Although propofol can be oxidized electrochemically, monitoring its concentration in biological matrixes is very challenging due to (i) low therapeutic concentration, (ii) high concentrations of easily oxidizable interfering compounds in the sample, and (iii) fouling of the working electrode. In this work we report the performance characteristics of an organic film coated glassy carbon (GC) electrode for continuous monitoring of propofol. The organic film (a plasticized PVC membrane) improved the detection limit and the selectivity of the voltammetric sensor due to the large difference in hydrophobicity between the analyte (propofol) and interfering compounds of the sample, e.g., ascorbic acid (AA) or p-acetamidophenol (APAP). Furthermore, the membrane coating prevented ele