BAGATOLLI LUIS ALBERTO
Capítulos de libros
Título:
Piercing membranas with peptides
Autor/es:
E.E. AMBROGGIO; LUIS A. BAGATOLLI; GOORMAGHTIGH, E.; FOMINAYA, J.; GASSET M.; A. LEITMANNOVA LIU
Libro:
Advances in Planar Lipid Bilayers and Liposomes, Volume 5.
Editorial:
Elsevier Inc
Referencias:
Año: 2007; p. 1 - 23
Resumen:
Disruption of the permeability barrier of biological membranes is one of the mechanisms
exploited by nature to allow the physiological or pathological chemical communication
between otherwise isolated like compartments. Despite the molecular complexity of these
membranes, the lipid bilayer backbone is the permeability guardian, and therefore the
universal target of numerous peptides and small proteins that act as perfect weapons. This
pathway of cell-life interference is primarily used by the peptides forming part of the innate host defence against pathogens, some of which are exploited as antibiotics in ectopic
infection treatments. Similarly, the phage holins, naturally tailored for allowing the release
of the phage progeny at the last stage of the lytic cycle, have their application in biotechnological contention and dairy industry. The necessity to modify and regulate the genome and transcriptome of living organism has demanded the access to cell interior without damage. The knowledge accumulated from the peptide?membrane interaction field has allowed the rational ??de novo?? design of novel peptide sequences that either alone, in combination or in tandem incorporate the capacity to produce the non-toxic membrane permeation events required for efficient gene transfer. RAWA, a 23 amino-acid peptide, serves as a paradigm of this synthetic approach.
exploited by nature to allow the physiological or pathological chemical communication
between otherwise isolated like compartments. Despite the molecular complexity of these
membranes, the lipid bilayer backbone is the permeability guardian, and therefore the
universal target of numerous peptides and small proteins that act as perfect weapons. This
pathway of cell-life interference is primarily used by the peptides forming part of the innate host defence against pathogens, some of which are exploited as antibiotics in ectopic
infection treatments. Similarly, the phage holins, naturally tailored for allowing the release
of the phage progeny at the last stage of the lytic cycle, have their application in biotechnological contention and dairy industry. The necessity to modify and regulate the genome and transcriptome of living organism has demanded the access to cell interior without damage. The knowledge accumulated from the peptide?membrane interaction field has allowed the rational ??de novo?? design of novel peptide sequences that either alone, in combination or in tandem incorporate the capacity to produce the non-toxic membrane permeation events required for efficient gene transfer. RAWA, a 23 amino-acid peptide, serves as a paradigm of this synthetic approach.
