Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina

NADIA OLIVERO; MIRELYS HERNANDEZ-MORFA; CORTES PAULO R; ECHENIQUE JOSE

BMC Genomics

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2022 vol. 23

1471-2164

n December 2019, deep sequencing analysis of lower respiratory tract samples from patients with coronavirus disease 2019 (COVID-19) led to the discovery of the novel human coronavirus associated with severe acute respiratory syndrome, known as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), in Wuhan, Hubei Province, China [1, 2].SARS-CoV-2 is an enveloped virus with a nonsegmented, single-stranded RNA genome that belongs to the Coronaviridae family. SARS-CoV-2 has 10 open reading frames (ORFs) that code for non-structural, structural, and accessory proteins [3].In general, RNA viruses have high mutation rates that correlate with their adaptation and evolution, traits considered essential for their spread [4]. Despite SARS-CoV-2 being at the low end of that spectrum due to its RNA proofreading capacity, it has clearly shown adaptability and the capacity to generate variants during its worldwide spread. The COVID-19 pandemic was officially declared by the World Health Orga