Resumen:
he Chlamydiae are obligate intracellular pathogens that
replicate within a membrane-bound vacuole, termed the ‘inclusion’. From
this compartment, bacteria acquire essential nutrients by selectively
redirecting transport vesicles and hijacking intracellular organelles.
Rerouting is achieved by several mechanisms including
proteolysis-mediated fragmentation of the Golgi apparatus, recruitment
of Rab GTPases and SNAREs, and translocation of cytoplasmic organelles
into the inclusion lumen. Given Chlamydiae's extended
coevolution with eukaryotic cells, it is likely that co-option of
multiple cellular pathways is a strategy to provide redundancy in the
acquisition of essential nutrients from the host and has contributed to
the success of these highly adapted pathogens.