New insights in Chlamydia: host interactions and pathogenesis.

HECTOR A. SAKA; DAMIANI, MARÍA T.

Frontiers in Cellular and Infection Microbiology

Frontiers Media SA

Lugar: Lausana; Año: 2023

2235-2988

hlamydia are ancient and successful pathogens, evolutionary distinct from mostbacteria and highly adapted to an intracellular lifestyle. To propagate, Chlamydia deploy aplethora of resources oriented to fulfill different steps of their pathogenic strategy, includinginfection and invasion of their host cells, the transition from infectious elementary bodiesto replicative reticulate bodies, establishing an intracellular replicative niche inside amembrane-enclosed compartment (the “inclusion”), transition back to elementarybodies and finally, exit of the host cell. Each of these steps involves complex and poorlyunderstood interactions with their hosts.As obligate intracellular pathogens, Chlamydia have evolved many strategies to acquirenutrients and manipulate cell pathways to evade the anti-bacterial responses elicited by thehost. Technical advances in imaging, high-throughput “omics”, sequencing, and genetictools have contributed to unraveling some of the chlamydial adaptive mechanisms