Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity.

ROJAS DELGADO, R.; JIMENEZ KAIRUZ, AF.; MANZO, RH.; GIACOMELLI, CE.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 463 p. 37 - 37

rug formulations with peroral administration that provide specific site delayed release at intestines are an important research area by both the academia and the pharmaceutical industries. In this work the capacity of layered double hydroxides-drug (LDH-D) hybrids to produce such release profile is exposed. With this purpose LDH-Ds containing either ibuprofen, naproxen and ketoprofen were synthesized. Afterwards, their structure and interfacial properties were correlated with the in vitro release profiles of LDH-D tablets in gastric and intestinal media. The hybrids exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the inorganic matrix. The hybrids compression leaded to highly stacked disposition of lamellar units, which turned the obtained tablets in kind of giant hybrid particles. Consequently, there is a slower and steadier release rate than that previously observed for particulate solid formulations. The release rate was quite slower in gastric