Apparent molar volumes of the anesthetic drugs procaine-HCl and lidocaine-HCl in water at temperatures from 278.15 to 313.15 K.

DELGADO, DR.; JIMENEZ KAIRUZ, AF.; MANZO, RH.; VARGAS, EF.; MARTINEZ, F.

Revista Colombiana de Ciencias Químico-Farmacéuticas

Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Farmacia - Publindex, Colciencias.

Lugar: Bogotá; Año: 2010 vol. 39 p. 57 - 57

0034-7418

idocaine-HCl and procaine-HCl are local anesthetic drugs widely used in minor chirurgic procedures, nevertheless, physicochemical information about their volumetric behavior, as well as for other aqueous properties, is not complete at present. In this context, in this article, densities of aqueous solutions of both drugs have been measured as a function of concentration (from 0.0500 to 0.5000) mol kg?1 at several temperatures, i.e. 278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 313.15 K. The apparent molar volumes and partial molar volumes at infinite dilution for the electrolyte drugs were calculated, whereas, the partial molar volumes at infinite dilution and partial molar expansibilities for the molecular forms were also calculated. The dependence of these properties with temperature is shown. The results are interpreted in terms of interaction solute-solvent.