Modelling drug release from a layered double hydroxide-ibuprofen complex.

ROJAS, R; PALENA, MC; JIMENEZ KAIRUZ, AF; MANZO, RH; GIACOMELLI, CE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 62-3 p. 15 - 15

rug delivery by layered double hydroxides (LDHs) is extensively studied due to the capacityof these solids to preserve the active agent and to modify its release rate and bioavailability. In this work, an ibuprofen-LDH complex was synthesized with high drug content (54 % w/w), incorporated both in the interlayer and on the surface. The mechanisms involved in the ibuprofen release process were studied as a function of the anion type (chloride, acetate, and phosphate) and concentration, and the pH of the release media. The experimental conditions selected were based on the composition of pharmaceutically relevant fluids such as gastric, intestinal and lysosomal simulated media. Three release mechanisms accounted for the rate and extent of the drug release: ion exchange (highly dependent on the anions), desorption and weathering (dependent on the pH). These mechanisms, together with the different solubility of the anionic and non-ionic ibuprofen species, also explained the release behavi