Self-organized nanoparticles based on drug-interpolyelectrolyte complexes as potential drug carriers: Physicochemical and in vitro drug release evaluations.

PALENA, MC; MANZO, RH; JIMENEZ KAIRUZ, AF.

SPRINGER

Lugar: Berlin; Año: 2012 vol. 14 p. 867 - 867

otential applications in drug delivery from nanostructures comprised of two oppositely charged polymethacrylates, eudragit® L100 (EL) and eudragit® EPO (EE), loaded with three model basic drugs (D), atenolol, propranolol and metroclopramide were evaluated. The self-organized nanoparticles based on drug-interpolyelectrolyte complexes (DIPEC), (EL-D50)-EEX, were obtained by mixing the aqueous dispersions of both polyelectrolytes at room temperature in an ultrasound bath. Dispersions of (EL-D50) neutralized with increasing proportions of EE exhibited a rise of turbidity, diffusion coefficients in the range of 2 to 8.10-8 cm2/s and high negative zeta potential . The sign of zeta potential was shifted from negative to positive by changes in composition of DIPEC. Freeze dried DIPEC were easily redispersed in water yielding almost the same parameters of fresh dispersions. Release experiments in Franz cells shown that DIPEC systems behave as a drug reservoir that slowly releases the drug in