Self-organized drug-interpolyelectrolyte nanocomplexes loaded with anionic drugs. Characterization and in vitro release evaluation.

PALENA, MC.; GARCÍA, MC.; MANZO, RH.; JIMENEZ KAIRUZ, AF.

EDITIONS SANTE

Año: 2015 vol. 30 p. 45 - 45

he current study is focused on physicochemical characterization and in vitro drug delivery evaluation of self-organized nanoparticles based on drug-interpolyelectrolyte complexes (DIPEC). The interaction between two oppositely charged polymethacrylates, Eudragit® EPO and L100, and four non-steroidal anti-inflammatory drugs, Salicylic Acid, Benzoic Acid, Ketoprofen and Naproxen were studied.DIPEC nanoparticles produce clear and stable aqueous dispersions where a remarkably high proportion of drug (D) (between 57-95%) is condensed with the polyelectrolyte (PE) under the form of ionic pairs. They exhibited particle sizes in the range of 120 to 320 nm and high positive zeta potentials, contributing to physical stability. The sign of zeta potential was shifted from positive to negative by changes in composition of DIPEC. Thermal analysis and X-ray diffraction patterns of freeze dried DIPEC showed the amorphous state of products and the complete interaction of the PE and D. Solid complexes