Study of the influence of formulation variables in bioadhesive emulgels using response surface methodology

OCHOA ANDRADE, A.; PARENTE, ME.; JIMENEZ KAIRUZ, AF.; BOINBASER, L.; TORREGROSSA, A.

AAPS PHARMSCITECH

SPRINGER

Lugar: Berlin; Año: 2017

1530-9932

he aim of the present work was to study the main formulation variables thatinfluence attributes of bioadhesive emulgels based on a combination of polymers, using response surface methodology (RSM). Bioadhesive products continue to gain attention in topical cutaneous administration as they allow long residence times on the application site,which is important when a long dermal action and a reduced product administration frequency are desired. A Box-Behnken design of experiments (DoE) was introduced to study the effect of formulation variables on quality attributes of the emulgels. The effects of concentration of carbomer interpolymer type A (Polym1), xanthan gum (Polym2) and mineral oil (Oil) on detachment force (Fdetch), spreadability (Spread), and phase separationby mechanical stress (PhSep) were investigated. RSM and desirability functions were applied for data analysis. Emulgels were further characterized by viscosity and extrudability measurements. Polym1 showed a positive effect