Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools

DE LAFUENTE, Y.; OCHOA-ANDRADE, A.; PARENTE, M.E.; PALENA, M.C.; JIMENEZ-KAIRUZ, A.F.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (PRINT)

Blackwell Publishing Ltd

Año: 2020 vol. 42 p. 548 - 548

0142-5463

bjective: The aim of the present study was to evaluate the influence of the incorporation of caffeine as a model active ingredient on the quality attributes of a bioadhesive emulgel formulation previously optimized by Quality by Design (QbD) tools. Emulgels are emerging topical drug delivery systems for cosmetic or pharmaceutical uses, which combine the advantages of both emulsions and gels. Methods: In this work, the observed and predicted values for spreadability, phase separation by centrifugation and detachment forces performed by texturometer were compared with those of the control and active-containing emulgel formulations. In addition, rheological properties, release of caffeine and comparative in vitro/ex vivo bioadhesion properties were evaluated using human skin. Results: The flow curves of emulgel formulations showed the typical pseudoplastic and no thixotropic flow with yield stress. The incorporation of active ingredient did not produce significant changes. All emulgels w