VILLARREAL MARCOS ARIEL
Congresos y reuniones científicas
Título:
Interaction of a Peripheral Acidic Protein with Anionic Lipid Membranes Insights from Molecular Simulations
Autor/es:
VANESA V. GALASSIA, MARCOS VILLARREAL, MARIANA BOLLO, GRACIELA BERBERIÁN, LUIS BEAUGÉ, GUILLERMO G. MONTICH
Reunión:
Congreso; XXXIX Reunión Anual de la Sociedad Argentina de Biofísica; 2010
Resumen:
ReP1 belongs to the FABP family, sharing the common terciary
motif of -barrel. This soluble protein up-regulates the Na+/Ca2+
exchanger of squid. It has been found to interact with anionic lipids
such as phosphatidilinositols and phosphatidic acids [1].
Its isoelectric point is 5.85, which leads to a net charge of -1.
This, together with its ability to interact with anionic lipids, makes it
a potential model to test the hypothesis that the binding and the
orientation of peripheral proteins to lipid membranes is driven by
the interaction of its macrodipole with the electric field of the
interface [2]
motif of -barrel. This soluble protein up-regulates the Na+/Ca2+
exchanger of squid. It has been found to interact with anionic lipids
such as phosphatidilinositols and phosphatidic acids [1].
Its isoelectric point is 5.85, which leads to a net charge of -1.
This, together with its ability to interact with anionic lipids, makes it
a potential model to test the hypothesis that the binding and the
orientation of peripheral proteins to lipid membranes is driven by
the interaction of its macrodipole with the electric field of the
interface [2]
