Molecular epidemiology of Hepatitis B virus in Córdoba, Argentina

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 p. 204 - 204

ackground: The analysis of the genomes of hepatitis B virus (HBV) identifies phylogenetic variants called genotypes, which may lead to distinct biological and clinical behaviors. Objectives: The aim of this study was to describe the current molecular epidemiology and genetic diversity of HBV in Córdoba, Argentina. Study design: A total of 52 HBV samples, 40 from HBV mono-infected and 12 from human immunodeficiency virus (HIV)-HBV co-infected patients, were sequenced in the S gene and in the basal core promoter-precore (BCP-pC) region. Results: Presence of subgenotypes F1b (35%) and F4 (17.5%), subgenotype A2 (37.5%), C (5.0%) (subgenotype could not be defined) and D (5.0%) (subgenotype D2, and the other could not be defined) were observed among mono-infected patients. The co-infected individuals displayed a different genotype distribution: sub-genotype A2 was the most common (75.0%), followed by subgenotype F1b (25.0%). Conclusions: These results showed two epidemiologic sc