Current phthalocyanines delivery systems in photodynamic therapy: an updated review

MIRETTI, MARIANA; PRUCCA, CESAR GERMAN; TEMPESTI, TOMAS CRISTIAN; BAUMGARTNER, MARIA TERESA

CURRENT MEDICINAL CHEMISTRY.

BENTHAM SCIENCE PUBL LTD

Año: 2021 vol. 28

0929-8673

hotodynamic therapy has emerged as an effective therapeutic alternative to treat oncological,cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapycombines the action of a photosensitizer with light in the presence of oxygen to generate reactiveoxygen species capable of reacting with cellular components resulting in injury and, inconsequence inducing cellular death. Most of the existing photosensitizers are lipophilicdifficulting their administration for clinical use. A strategy to overcome the lack of solubility ofphotosensitizers in aqueous media is to incorporate them into different delivery systems.Liposomes, gold-nanoparticles, polymeric nanoparticles, dendrimers, and polymeric micelles,constitute some of the most used carriers in photodynamic therapy. The application ofnanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy andreduce side-effects associated with the photosensitizer administration. This review add