Evaluation of ZnPc and one amino derivative effectiveness for PDT on glioblastoma cells

MIRETTI, M.; VELAZQUEZ, F.N.; BAUMGARTNER, M.T.; CAPUTTO, B.L; TEMPESTI, T.C.; PRUCCA, C.G.

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de BioCiencias; 2017

Glioblastoma multiforme is a type of tumor of the central nervous system (CNS), known for being one of the worst and fast-growing brain tumor. This type of cancer presents a poor prognosis after diagnosis with a survival rate of ~one year. The current protocol for glioblastoma treatment consists in the surgical excision of the primary tumor followed by radio and chemotherapy. Photodynamic therapy (PDT) is a well-known therapeutic approach that combine two components (light and a photosensitizer (PS)) to induce cell death based on the generation of singlet oxygen (1O2) and/or reactive oxygen species (ROS), by photochemical reactions. Phthalocyanines (Pcs), are excellent second generation photosensitizers for PDT.