Photoinactivation effect on nontuberculous mycobacteria using zn-phthalocyanine loaded into liposomes.

MARIANA MIRETTI; TEMPESTI, TOMAS C.; JURI, LETICIA; PERALTA, ALEJANDRA; COSIANSI, MARÍA C.; BAUMGARTNER, MARIA T.

Cordoba

Congreso; CONGRESO CONJUNTO SAIB-SAMIGE 2021; 2021

SAIB-SAMIGE

Nontuberculous mycobacteria (NTM) represent a heterogeneous group of environmental bacteria. NTM infections are difficult to diagnose and include many species that can cause severe disease as lymphadenitis, lung, skin, bone, and soft tissue infections, or disseminated disease.[1] NTM infections are multisystem and multigenic-based diseases and depend on the entry and host susceptibility factors. Disseminated NTM infections impact severely on immunocompromised patients.[2] Among the most clinically relevant species of rapid growth NTMs are Mycobacterium chelonae and Mycobacterium fortuitum.Antimicrobial photodynamic therapy (aPDT) has reemerged over the last decade as an alternative to eliminate pathogens, principally those antimicrobials resistant. aPDT involves a compound innocuous in the darkness denominated photosensitizer (PS), light, and oxygen. The excitation of PS leads to reactive species oxygen (ROS) and/or singlet oxygen (1O2). These species react with biomolecules, producing cell damage and microorganism destruction.[3] Phthalocyanines (Pcs) are considered promising second-generation PS. However, due to its lipophilic nature, Pcs tend to form aggregates in aqueous media, and consequently, the efficacy of aPDT decreases.[4]